KMID : 0043320100330040515
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Archives of Pharmacal Research 2010 Volume.33 No. 4 p.515 ~ p.521
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A New Phenylpropane Glycoside from the Rhizome of Sparganium stoloniferum
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Lee Kang-Ro
Lee Seung-Young Choi Sang-Un Lee Jei-Hyun Lee Dong-Ung
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Abstract
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The purification of the MeOH extract from the rhizome of Sparganium stoloniferum Buch.- Hamil. (Sparganiaceae) using column chromatography furnished one new phenylpropanoid glycoside (7) and known phenolic compounds (1-6, and 8-13). The structural elucidation of 7 was based on 1D- and 2D-NMR spectroscopic data analysis to be ¥â-D-(6-O-trans-feruloyl) fructofuranosyl-¥á-D-O-glucopyranoside. Compounds 1-6, and 8-13 were elucidated by spectroscopy and confirmed by comparison with reported data; 24-methylenecycloartanol (1), phydroxybenzaldehyde (2), ferulic acid (3), p-coumaric acid (4), vanillic acid (5), ¥â-D-(1-O-acetyl-3-O-trans-feruloyl)fructofuranosy-¥á-D-2¡¯,4¡¯,6¡¯.-O-triacetyglucopyranoisde (6), ¥â-D-(1-O-acetyl- 3,6-O-trans-diferuloyl)fructofuranosyl-¥á-D-2¡¯,4¡¯,6¡¯.-O-triacetylglucopyranoisde (8), hydroxytyrosol acetate (9), hydroxytyrosol (10), isorhamnetin-3-O-rutinoside (11), n-butyl-¥á-D-fructofuranoside (12), and n-butyl-¥â-D-fructopyranoside (13). Compounds 3 and 9-13 were isolated for the first time from this plant. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
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KEYWORD
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Sparganium stoloniferum, Sparganiaceae, Phenylpropane glycoside
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